S-Acetyl Glutathione - 300 mg, 60 capsules

Supports detoxification, brain health and cellular functions.

• Supports healthy cell function and healthy aging
• Supports liver detoxification
• Supports the brain and nervous system

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Research-Supported Benefits:

Supports Cellular Health. Glutathione is our body’s most abundant antioxidant, playing a critical role in protecting the body from oxidative stress. Glutathione helps to regulate several cellular events, such as gene expression, protein and DNA synthesis, immune response and cell growth. In addition to being an antioxidant itself, glutathione is also a cofactor for several other antioxidant enzymes^1-3

Supports Detoxification. Glutathione supports both phase 1 and phase 2 detoxification in the liver, helping to neutralize and excrete harmful toxins. Glutathione not only binds to toxins before they can bind to and damage cells, but it also transforms toxins into a water-soluble form for further filtering and easy excretion through the urinary system. Dysfunctional detoxification pathways can lead to liver damage, DNA damage and increased cellular stress.⁴

Supports Healthy Aging. Glutathione deficiency contributes to oxidative stress, which can accelerate aging and the development of age-related disorders. Our mitochondria—the cells’ energy production centers—are dependent on glutathione, which can cross mitochondrial membranes and minimize reactive oxygen species (ROS) buildup. Healthy mitochondrial function is vital for healthy aging.⁵

Supports Brain and Nervous System Health. Glutathione is necessary for neutralizing ROS in the brain, which can lead to poor cognitive function. Research shows that reduced glutathione levels in the brain are linked to the development of neurological conditions.^{6, 7}

References:

1. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489-492. doi:10.1093/jn/134.3.489 

2. Chatterjee A. Reduced glutathione: a radioprotector or a modulator of DNA-repair activity?. Nutrients. 2013;5(2):525-542. Published 2013 Feb 7. doi:10.3390/nu5020525 doi:10.3390/nu5020525 

3. Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009;30(1-2):1-12. doi:10.1016/j.mam.2008.08.006 

4. Pizzorno J. Glutathione!. Integr Med (Encinitas). 2014;13(1):8-12. PMID: 26770075 

5. Marí M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009;11(11):2685-2700. doi:10.1089/ARS.2009.2695 

6. Dringen R. Metabolism and functions of glutathione in brain. Prog Neurobiol. 2000;62(6):649-671. doi:10.1016/s0301-0082(99)00060-x 

7. Mandal PK, Saharan S, Tripathi M, Murari G. Brain glutathione levels--a novel biomarker for mild cognitive impairment. Biol Psychiatry. 2015;78(10):702-710. doi:10.1016/j.biopsych.2015.04.005 

8. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390(3):191-214. doi:10.1515/BC.2009.033 

9. Di Paola R, Modafferi S, Siracusa R, et al. S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation. Int J Mol Sci. 2022;23(8):4429. Published 2022 Apr 17.