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Promotes Cardiovascular Health. Pine bark extract contains antioxidants, such as proanthocyanidins, that may contribute to maintaining heart health in older adults by improving blood flow and increasing plasma antioxidant capacity. In addition, its polyphenol content has been shown to modulate LDL cholesterol levels in human studies. (1)
Supports Cognitive Function and Brain Plasticity.Pine bark extract has been shown to promote autophagy, an internal process that removes dysfunctional cells, which may be beneficial for brain function and plasticity by maintaining neuron health and facilitating the formation of new neural connections. (2)
Improves Skin Health and Appearance. Pine bark extract is rich in proanthocyanins, compounds that may support collagen production and improve skin health by protecting against UV damage, promoting skin elasticity, and reducing the appearance of age-related skin issues. (3)
Protects Joints from Wear and Tear. The antioxidants in pine bark extract may help reduce joint discomfort and protect joints from age-related damage by neutralizing free radicals that cause oxidative stress and contribute to the breakdown of cartilage. (4,5)
Improves DNA Integrity. Pine bark extract supports DNA damage reduction as shown in a 12-week study of human subjects via enhanced capacity to control free radical damage in cells. (3, 6)
May Improve Athletic Performance and Recovery. Some research suggests that pine bark extract could enhance cellular antioxidant levels, possibly promoting better athletic performance and recovery by reducing muscle fatigue and supporting muscle repair processes. (7)
References:
1. Nakayama S, Kishimoto Y, Saita E, et al. Pine bark extract prevents low-density lipoprotein oxidation and regulates monocytic expression of antioxidant enzymes. Nutrition Research. 2015;35(1):56-64. doi:10.1016/j.nutres.2014.10.010
2. Theadom A, Mahon S, Barker-Collo S, et al. Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo-controlled RCT. Eur J Neurol. 2013;20(8):1135-1144. doi:10.1111/ene.12099
3. Senthilmohan ST, Zhang J, Stanley RA. Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects. Nutrition Research. 2003;23(9):1199-1210. doi:10.1016/S0271-5317(03)00127-1
4. Yazaki Y. Utilization of flavonoid compounds from bark and wood: a review. Natural Product Communications. 2015;10(3):1934578X1501000. doi:10.1177/1934578X1501000333
5. Li YY, Feng J, Zhang XL, Cui YY. Pine bark extracts: nutraceutical, pharmacological, and toxicological evaluation. J Pharmacol Exp Ther. 2015;353(1):9-16. doi:10.1124/jpet.114.220277
6. Kim DS, Kim MS, Kang SW, Sung HY, Kang YH. Pine bark extract enzogenol attenuated tumor necrosis factor-α-induced endothelial cell adhesion and monocyte transmigration. J Agric Food Chem. 2010;58(11):7088-7095. doi:10.1021/jf1005287
7. O’Callaghan YC, Drummond E, O’Gorman DM, O’Brien NM. Antioxidant and pro-apoptotic effects of marine-derived, multi-mineral aquamin supplemented with a pine bark extract, enzogenol, and a green tea extract, sunphenon. Journal of Medicinal Food. 2013;16(10):920-926. doi:10.1089/jmf.2012.0258
Supplement Facts | ||
---|---|---|
Serving Size: 2 Capsules | ||
Servings Per Container: 30 | ||
Amount Per Serving | %DV | |
Enzogenol® Pine Bark Extract (Pinus radiata) | 250 mg | † |
† Daily value not established |